PCL-PEG-COOH (COOH: Acid) - Creative PEGWorks

Description

PCL-PEG-COOH is an amphiphilic block copolymer consisting of a hydrophilic polyethylene glycol (PEG) and a hydrophobic polycaprolactone (PCL). The PEG polymer is capped a carboxylic acid COOH group. The hydrophobic block PCL terminates with a hydroxyl group. Biocompatible PEGylated copolymers with biodegradable polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of the polyester block depends on the molecular weight and the spacer between ester groups (lactide, glycotide or caprolactone). PEG-PCL with other MWs is also offered.

References

1) Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo, Cell Death & Disease, 10, 702 (2019), DOI: 10.1038/s41419-019-1870-0

2) Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells, Int. J. Mol. Sci. 2021, 22, 1019. DOI: 10.3390/ijms22031019

3) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600-3, Text.

Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Description

References

Get In Touch