Biotin-Chitosan-Fluorescein, 200-500 cP, 85% DDA
Chitosan is labeled with both biotin and fluorescein, Ex/Em wavelength 494/518 nm. Purity: >95% lyophilized powder. Standard Degree of substitution: 1 mol % substitution for each dye and at least one biotin and one fluorescein molecule per polymer. Chitosan labeled with other types of fluorescent dyes may be offered through our custom synthesis.
Chitosan is produced by deacetylation  of  chitin, which is the structural  element  in the  exoskeleton  of  crustaceans  (such as crabs and shrimp) and cell walls of  fungi. The degree of deacetylation (%DD) can be determined by  NMR spectroscopy from 60 to 100%.Chitosan products are characterized by either its MW or its viscosity.  The  amino  group in chitosan has a  pKa value of ~6.5.
1) Intrinsic viscosity–molecular weight relationship for chitosan, Journal of Polymer Science: Part B: Polymer Physics, Vol. 38, 2591–2598 (2000), Text. Link.
2) Preparation and Characterization of Chitin and Chitosan A Review, Journal of Aquatic Food Product Technology, 1995, 4(2): 27-52
3) Applications of Chitosan and Chitosan Derivatives in Drug Delivery, Advances in Biological Research, 2011, 5 (1): 28-37
4) Molecular weight dependent antimicrobial activity by chitosan, New Macromolecular Architecture and Functions (in English), Proceedings of the OUMS, 95, 2nd, Toyonaka, Japan, June 2-5, 1995 , 199-207.
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