PLA-PEG-Maleimide is a useful reagent to prepare core-shell nanoparticles displaying maleimide groups on particle surface. The thiol-reactive maleimide is for conjugation with peptide or proteins bearing free thiols. PEG-PLA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) and a hydrophobic block polylactic acid or polylactide (PLA). The hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres.
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