PEG-PLA - Creative PEGWorks | PEG Products Leader

Description

PEG-PLA is an amphiphilic AB diblock copolymer. The two blocks are hydrophilic block polyethylene glycol (PEG) and hydrophobic block polylactic acid or polylactide (PLA). The PEG segment is capped with a methyl ether group (i.e. mPEG). The hydrophobic PLA block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). PEG-PLA with other MWs not listed is also available.

References

1. Increasing Stability of Biotin Functionalized Electrospun Fibers for Biosensor Applications, 2017, ACS Appl Mater Interfaces, DOI: 10.1021/acsami.6b14348, Text.

2. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.

3) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600Ã¢â‚¬“3, Text.

4. Preparation, characterization and properties of polylactide (PLA) – poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J Appl Polym Sci 1990;39: 1Ã¢â‚¬“9, Text.

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Description

References

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