PEG-PLA is an amphiphilic AB diblock copolymer. The two blocks are hydrophilic block polyethylene glycol (PEG) and hydrophobic block polylactic acid or polylactide (PLA). The PEG segment is capped with a methyl ether group (i.e. mPEG). The hydrophobic PLA block terminates with a hydroxyl group.
PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). PEG-PLA with other MWs not listed is also available.
1. Increasing Stability of Biotin Functionalized Electrospun Fibers for Biosensor Applications, 2017, ACS Appl Mater Interfaces, DOI: 10.1021/acsami.6b14348, Text.
2. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.
3) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600â€“3, Text.
4. Preparation, characterization and properties of polylactide (PLA) – poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J Appl Polym Sci 1990;39: 1â€“9, Text.
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