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Functional Poloxamer / Pluronic Copolymer

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Functional Poloxamer / Pluronic Copolymer

PPO-120
Amine-P403-Amine
PPO-115
Maleimide-P407-Maleimide
PPO-116
Biotin-P407-Biotin
PPO-117
Amine-P407-Amine
PPO-118
NHS-P407-NHS
PPO-107
Biotin-P188-Biotin
PPO-103
Acrylamide-P188-Acrylamide
PPO-109
Acrylate-P188-Acrylate
PPO-119
Thiol-P407-Thiol
PPO-131
Acrylate-Synperonic PE/P84-Acrylate
PPO-121
Acrylate-Pluronic F-127-Acrylate
MTO-POLO
Functional Poloxamer, custom synthesis
PPO-114
Sulfonic acid-P188-Sulfonic acid
PPO-112
Methylamine-P188-Methylamine
PPO-111
Dimethylamine-P188-Dimethylamine
PPO-108
Thiol-P188-Thiol
PPO-106
Amine-P188-Amine
PPO-104
Maleimide-P188-Maleimide
PPO-102
Azide-P407-Azide
PPO-101
Azide-P188-Azide

Description

Functional Poloxamer is available through both catalog products and custom synthesis service. The functional groups can be azide, maleimide, thiol, alkyne for click chemistry, NHS ester, amine, acrylate. Functional Poloxamer are nonionic triblock copolymers. Poloxamer has a central hydrophobic chain of poly(propylene oxide) PPO flanked by two hydrophilic chains of poly(ethylene oxide) PEO or PEG.  Poloxamers are also known by the trade names such as Pluronic, Kolliphor and Synperonic. Pluronic F68 is the same as Poloxamer 188 (P188). Pluronic F127  is the same as Poloxamer 407 (P407). Poloxamer 403 is the same as Pluronic® P123. Poloxamer are commonly named with the letter P followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the PPO core, and the last digit multiplied by 10 gives the percentage PEO or PEG content. P407 = poloxamer with a PPO molecular mass of 4000 g/mol and a 70% PEO content. For Pluronic tradenames, the letter to define its physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) multiplied by 300, indicates the approximate molecular weight of PPO; and the last digit multiplied by 10 gives the percentage PEO content. Pluronic L61 indicates a PPO molecular mass of 1800 g/mol and a 10% PEO content.

Properties

Poloxamers are triblock copolymers of PEO and PPO available in different molecular weights and PPO/PEO ratios in the format of PEO-PPO-PEO. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules. This ability to form micelles  and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).

Another important property of Poloxamers is their thermogelling behavior: water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures.

A new type of reverse block copolymer in the format of PPO-PEO-PPO such as Pluronic 25R4 is a highly effective block copolymer surfactant with terminal secondary hydroxyl groups. It is specifically designed as an ethylene oxide and propylene oxide reverse block copolymer, providing unique properties for various applications. This surfactant acts as a dispersant, offering excellent associative thickening, dispersing, and wetting characteristics with minimal environmental impact.

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