Catalog No. : PPE-403
Product Name : PEG-g-LPEI, PEG 550, PEI 22k, PEG/PEI ratio 15
Description :

This product is a graft copolymer of linear PEI with multiple PEGs. The PEG to PEI ratio is the average number of PEGs per PEI.  For 22,000 MW PEI, PEG/PEI ratio of 15 is roughly 3% of PEI units grafted with PEGs. Custom service is provided to produce PEG-PEI reagents with any MW of PEI and any MW of PEG at any graft ratio PEG-g(x)-PEI.

PEG-PEI, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG) are well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA). By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can be prepared with a dynamic range of size, surface charge, and stability, which all are important to the transfection efficiency. PEG-PEI copolymers can be synthesized with customer specified MW.


1. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.

2. Critical Length of PEG Grafts on LPEI/DNA Nanoparticles for Efficient in Vivo Delivery, ACS Biomater. Sci. Eng. 2016, 2, 567−578, Text.

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