Catalog No. : PPE-303
Product Name : PEG-g-PEI , PEG 1k, PEI 25k, PEG/PEI ratio 30
Description :

This product is a graft copolymer of branched PEI, which is modified with multiple PEGs of indicated MW. The PEG to PEI ratio is the average number of PEGs per PEI.  For 25,000 MW PEI, PEG/PEI ratio of 30 is roughly 5% of PEI units grafted with PEGs. Custom service is provided to produce PEG-PEI reagents with any MW of PEI and any MW of PEG at any graft ratio PEG-g(x)-PEI, x is the PEG to PEI ratio.

PEG-PEI, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG) are well-studied compounds that markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA). By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can be prepared with a dynamic range of size, surface charge, and stability, which all are important to the transfection efficiency. PEG-PEI copolymers can be synthesized with customer specified MW.

References:

1. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy, RSC Adv., 2016, 6, 105871-105877, Text.

2. Critical Length of PEG Grafts on LPEI/DNA Nanoparticles for Efficient in Vivo Delivery, ACS Biomater. Sci. Eng. 2016, 2, 567−578, Text.

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Price :
 
 
$800/500mg
$1,200/1g
$2,600/5g
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