PLGA-PEG-COOH, custom synthesis

PLGA-PEG-COOH, custom synthesis

Catalog No:MTO-PLGAA
Product Name:PLGA-PEG-COOH, custom synthesis
In Stock: Yes
Interested in Bulk Orders? Please contact us here

Description

PLGA-PEG-Acid is a diblock copolymer with an acid group at the distal end of PEG. PLGA-PEG-COOH of any MW of PEG and PLGA as well as L to G ratio can be custom synthesized to meet your project need. PEG-PLGA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The PEG polymer is capped a methyl ether group, and the hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone).

Properties

PLGA – poly(lactide-co-glycolide) copolymer are available at a wide range of molecular weight (MW) and monomer (lactide to glycolide) ratios. PLGA can be dissolved in a wide range of solvents – higher lactide polymers can be dissolved using chlorinated solvents whereas higher glycolide polymers will require the use of fluorinated solvents such as hexafluoroisopropanol (HFIP) and perfluoroacetone.

References

1) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.

Get In Touch

If you have any questions, please submit an online inquiry.

"*" indicates required fields

Your Name*
Do you wish to receive emails for new product introduction and sale promotions?
By submitting this form, you are consenting to our privacy policy.
This field is for validation purposes and should be left unchanged.