PLA-PEG-NHS, custom synthesis

PLA-PEG-NHS, custom synthesis

Catalog No:MTO-PLANH
Product Name:PLA-PEG-NHS, custom synthesis
In Stock: Yes
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Description

PLA-PEG-NHS is a useful reagent to prepare core-shell nanoparticles displaying amine-reactive succinimidyl NHS ester. The NHS ester is for conjugation with peptide or proteins bearing free amine. PEG-PLA is an amphiphilic AB diblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic block polylactic acid or polylactide (PLA). The hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres.

References

1) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.

2) Bioerodible Hydrogels Based on Photopolyrneried Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macrorners, Macromolecules, 26, 1993: 581—537, Text.

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