Description
PEG-PCL is an amphiphilic block copolymer consisting of a hydrophilic polyethylene glycol (PEG) and a hydrophobic polycaprolactone (PCL). The PEG polymer is capped a methyl ether group (i.e. mPEG). The hydrophobic block terminates with a hydroxyl group. Biocompatible PEGylated copolymers with biodegradable polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of the polyester block depends on the molecular weight and the spacer between ester groups (lactide, glycotide or caprolactone). PEG-PCL with other MWs is also offered.
References
1) Site-Specific Addressing of Particles and Coatings via Enzyme-Mediated Destabilization, Catalysts 2019, 9, 354; doi:10.3390/catal9040354
2) Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo, Cell Death & Disease, 10, 702 (2019), DOI: 10.1038/s41419-019-1870-0
3) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600-3, Text.
4) Cyclic RGDfK- and Sulfo-Cy5.5-functionalized mPEG-PCL theranostic nanosystems for hepatocellular carcinoma, Journal of Industrial and Engineering Chemistry, 2021, 204-213, Text.
5) Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension, Nanomedicine: Nanotechnology, Biology and Medicine, 2021, 102417, Text.
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