PEG-b-LPEI is a block copolymer of linear PEI (LPEI) with a linear PEG. The terminal end of PEG is an inert, nonreactive methoxy group.
PEG-b-LPEI, copolymers of cationic poly(ethylene imine) (PEI) and polyethylene glycol (PEG). The copolymer is useful to markedly improve the in vitro and in vivo delivery of oligonucleotides and nucleic acids (DNA, siRNA). By varying the MW of PEI and PEG, PEG-PEI drug conjugates, polyplexes or nanoparticles can have a dynamic range of size, surface charge, and stability. These properties are all important to the transfection efficiency. PEG-b-LPEI copolymers is available with customer specified MW.