PCL-PEG-PCL, PCL(5000)-PEG(10000)-PCL(5000)
PCL-PEG-PCL is an amphiphilic ABA triblock copolymer consisting of a hydrophilic block polyethylene glycol (PEG) and two hydrophobic block polycaprolactone. The hydrophobic blocks terminate with a hydroxyl group. Biocompatible PEGylated copolymers with biodegradable polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The molecular weight of each block is shown in the parenthesis following the name of each block.
1) Site-Specific Addressing of Particles and Coatings via Enzyme-Mediated Destabilization, Catalysts 2019, 9, 354; doi:10.3390/catal9040354
2) Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo, Cell Death & Disease, 10, 702 (2019), DOI: 10.1038/s41419-019-1870-0
3) Polycaprolactone–poly(ethylene glycol) block copolymer, I: synthesis and degradability in vitro. Polym. Adv. Technol., 4: 363–366, Text.
4) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600–3, Text.
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