Description
mPEG-Dendro Azide consists of a linear PEG conjugated to one perfect dendrimer terminated with azide groups. This series of products feature a bisMPA dendrimer with a definite number of functional end groups (such as azide). The dendrimer option in this series of products includes G2, G3 and G4 generations having 4, 8, and 16 end functional groups, respectively. mPEG-Dendro Azide through click chemistry delivers a large number drug payload for novel drug delivery systems.
Properties
PEG 2k, G2: MW is 2,903 g/mol.
PEG 2k, G3: MW is 3,925 g/mol.
PEG 2k, G4: MW is 5,966 g/mol.
PEG 5k, G2: MW is 5,900 g/mol.
PEG 5k, G3: MW is 6,920 g/mol.
PEG 5k, G4: MW is 8,962 g/mol.
Products are fully characterized by HNMR, CNMR and SEC (GPC) or MALDI-MS. Full analytical data and ChemDraw structure of each generation are available upon request.
GPC – Eluent: DMF, Calibration: PMMA
Soluble in Alcohols, THF, DMF, DMSO and Chloroform.
References
1. High water content mouldable hydrogels by mixing clay and a dendritic molecular binder, Nature, 2010, 463, 339-343. Â Text.
2. Linear dendritic block copolymers as promising biomaterials for the manufacturing of soft tissue adhesive patches using visible light initiated thiol-ene coupling chemistry. Adv. Funct. Mater. 2015, 25, 6596-6605. Â Text.
3. Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research, Chem. Soc. Rev. 2013, 42, 5858-5879. Â Text.
4. Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine PAMAM dendrimers, Biomaterials 2012, 33, 1970-1981. Â Text.
5. Multifunctional PEG: Synthesis, characterization and potential application of dendritic-linear-dendritic block copolymer hybrids. Macromolecules 2013, 46(10), 3726-3736. Â Text.
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