Biotin-P407-Biotin
Biotin-F127-Biotin is the same as Biotin-P407-Biotin.
Pluronic F127 is generally regarded as safe (GRAS) by regulatory bodies like the FDA for pharmaceutical use. Pluronic F127 (also denoted as F-127 ), a widely utilized non-ionic, amphiphilic triblock copolymer in pharmaceutical and biomedical applications. This material is formally classified as poloxamer 407 (P407).
Poloxamers  are triblock  copolymers of PEO)and PPO available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules. This ability to form micelles  and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).
Another important property of Poloxamers is their thermogelling behavior: water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures.
1. Formulation of Poloxamers for Drug Delivery, J Funct Biomater. 2018 Mar; 9(1): 11. doi:Â Â 10.3390/jfb9010011
2.  Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system, doi: 10.1016/j.apsb.2017.03.002
3. Poloxamer overview, Link
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