Description
Amine-P403-Amine is the same as Amine-Pluronic P123-Amine
Poloxamer 403 is a non-ionic, triblock copolymer belonging to the poloxamer family, which consists of polyoxyethylene (PEO) and polyoxypropylene (PPO) blocks arranged in the structure PEO-PPO-PEO. It is also designated as Pluronic® P123 in commercial nomenclature. This compound serves primarily as a surfactant and emulsifying agent in pharmaceutical and cosmetic formulations. Chemical and Physical Properties: Molecular Formula and Structure: The polymer features hydrophilic PEO blocks flanking a hydrophobic PPO block, enabling amphiphilic behavior. The average molecular weight is approximately 5,750 Da. Appearance: It presents as a white, waxy powder. CAS Number: 9003-11-6.
Properties
Poloxamers are triblock copolymers of PEO and PPO available in different molecular weights and PPO/PEO ratios in the format of PEO-PPO-PEO, also called PEG-PPG-PEG. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules. This ability to form micelles  and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).
Another important property of Poloxamers is their thermogelling behavior: water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures.
A new type of reverse block copolymer in the format of PPO-PEO-PPO (PPG-PEG-PPG) such as Pluronic 25R4 is a highly effective block copolymer surfactant with terminal secondary hydroxyl groups. It is specifically designed as an ethylene oxide and propylene oxide reverse block copolymer, providing unique properties for various applications. This surfactant acts as a dispersant, offering excellent associative thickening, dispersing, and wetting characteristics with minimal environmental impact.
References
1. Formulation of Poloxamers for Drug Delivery, J Funct Biomater. 2018 Mar; 9(1): 11. doi:Â Â 10.3390/jfb9010011
2.  Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system, doi: 10.1016/j.apsb.2017.03.002
3. Poloxamer overview, Link
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