Description
Acrylate-P188-Acrylate or Acrylate-F68-Acrylate.
P188 copolymer refers to Pluronic F68, a non-ionic, amphiphilic triblock copolymer widely recognized in pharmaceutical, biomedical, and industrial formulations. It is formally designated as poloxamer 188. The following presents a structured analysis of its composition, properties, and applications, derived from authoritative chemical and scientific sources. Chemical Structure and Composition: Pluronic F68 exhibits a linear ABA triblock structure with the formula HO(CH₂CH₂O)₇₅(CH₂CH(CH₃)O)₃₀(CH₂CH₂O)₇₅H, or EO₇₅PO₃₀EO₇₅, where: EO represents ethylene oxide (poly(ethylene oxide), PEO; hydrophilic segments), PO represents propylene oxide (poly(propylene oxide), PPO; hydrophobic segment). Key specifications include: Average molecular weight: Approximately 8,400 Da. Hydrophilic content: ~80% PEO by weight, conferring high water solubility. CAS Number: 9003-11-6.
Properties
Poloxamers are triblock copolymers of PEO and PPO available in different molecular weights and PPO/PEO ratios in the format of PEO-PPO-PEO. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules. This ability to form micelles  and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC).
Another important property of Poloxamers is their thermogelling behavior: water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures.
A new type of reverse block copolymer in the format of PPO-PEO-PPO such as Pluronic 25R4 is a highly effective block copolymer surfactant with terminal secondary hydroxyl groups. It is specifically designed as an ethylene oxide and propylene oxide reverse block copolymer, providing unique properties for various applications. This surfactant acts as a dispersant, offering excellent associative thickening, dispersing, and wetting characteristics with minimal environmental impact.
References
1. Formulation of Poloxamers for Drug Delivery, J Funct Biomater. 2018 Mar; 9(1): 11. doi:Â Â 10.3390/jfb9010011
2.  Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system, doi: 10.1016/j.apsb.2017.03.002
3. Poloxamer overview, Link
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