PLGA – poly(lactide-co-glycolide) copolymer are available at a wide range of molecular weight (MW) and monomer (lactide to glycolide) ratios. PLGA-PEG-PLGA can be dissolved in a range of common organic solvents depending on its composition especially the L to G ratio and the total PLGA MW. As the MW goes up and the content of G goes up, its solubility gets poor in common organic solvent. Typically PLGA-PEG-PLGA at lower MW or greater L content can be dissolved in chlorinated solvents, such as dichloromethane or chloroform much easier, and sometimes in water-miscible solvents, like acetone, acetonitrile and THF depending on the total MW. PLGA-PEG-PLGA with a higher amount of G is better dissolved by fluorinated solvents, like hexafluoroisopropanol and perfluoroacetone.