PEG-PLGA Copolymers | Order In-Stock or Custom Synthesis

PEG-PLGA is an amphiphilic diblock copolymer. The two blocks consist of a hydrophilic block polyethylene glycol (PEG) and a hydrophobic block poly(lactide-co-glycolide) (PLGA). The PEG polymer is capped with a methyl ether or methoxy (i.e. mPEG). The MW of PEG and PLGA and the ratio of lactide to glycolide are important properties of drug delivery system. The hydrophobic block terminates with a hydroxyl group. PEGylated copolymers with biodegradable and biocompatible polyester segments is useful to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of polyester segments depend on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone).

Properties

PEG-PLGA can be dissolved in a range of common organic solvents depending on its composition especially the L to G ratio and the total PLGA MW. As the MW goes up and the content of G goes up, its solubility gets poor in common organic solvent. Typically PEG-PLGA at lower MW or greater L content can be dissolved in chlorinated solvents, such as dichloromethane or chloroform much easier, and sometimes in water-miscible solvents, like acetone, acetonitrile and THF depending on the total MW. PEG-PLGA with a higher amount of G is better dissolved by fluorinated solvents, like hexafluoroisopropanol and perfluoroacetone.

PEG-PLGA

Description

Properties

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