PCL-PEG-NHS - Creative PEGWorks | PEG Products Leader

Description

PCL-PEG-NHS is an amphiphilic block copolymer consisting of a hydrophilic polyethylene glycol (PEG) and a hydrophobic polycaprolactone (PCL). The PEG polymer is capped an activated carboxylic acid, succinimidyl NHS ester. The hydrophobic block PCL terminates with a hydroxyl group. Biocompatible PEGylated copolymers with biodegradable polyester segments can be used to prepare core-shell micelles, nanoparticles and microspheres. The hydrolytic degradability of the polyester block depends on the molecular weight and the spacer between ester groups (lactide, glycotide or caprolactone). PEG-PCL with other MWs is also offered.

References

1) Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo, Cell Death & Disease, 10, 702 (2019), DOI: 10.1038/s41419-019-1870-0

2) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600Ã¢â‚¬“3, Text.

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Description

References

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