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Dendro Alkyne-PEG-Dendro Alkyne

Dendro Alkyne-PEG-Dendro Alkyne

Description

Dendro Alkyne-PEG-Dendro Alkyne or Hyperbranched Alkyne-PEG-Hyperbranched Alkyne consists of a linear PEG core with two hyperbranched, dendritic wedges at both ends of the PEG chain. This series of products feature linear PEG functionalized with a bisMPA dendrimer wedge with an average number of functional end groups (such as acetylene).   The hyperbranched structure has multiple pseudo-generations of dendrimers G3, G4, G5 and G6 having 16, 32, 64, and 128 end functional groups, respectively. Alkyne dendrimer reacts with azide-containing molecules for bioconjugation of a high number of drug payload.

Properties

The MW for the entire molecule for G3, G4, G5 and G6 is 13,900, 17,900, 26,100 and 42,400 gram per mole. The MW of entire molecule is calculated from the MW of the linear PEG core combined with the number of dendritic structure and the functional groups.

Products are fully characterized by HNMR, CNMR and SEC (GPC) or MALDI-MS. Full analytical data and ChemDraw structure of each generation are available upon request.

GPC – Eluent: DMF, Calibration: PMMA

Soluble in Alcohols, THF, DMF, DMSO and Chloroform.

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