Activated PLGA have ready-to-react functional groups that can be used to conjugate to drugs or dye labels. Activated PLGA can also be crosslinked with itself or other reactive polymers to form nanoparticles, microspheres or hydrogels. Reactive groups include acrylate, methacrylate, etc. Contact us to discuss your needs.
PLGA - poly(lactide-co-glycolide) copolymer is used in a number of Food
and Drug Administration (FDA) approved therapeutic devices, owing to its
biodegradability and biocompatibility. PLGA undergoes hydrolysis in the
body to produce its original monomers, lactic acid and glycolic acid,
which are two by-products of various metabolic pathways. PLGA are
available at a wide range of molecular weight (MW) and monomer (lactide
to glycolide) molar ratios. Typical L to G feed ratios include 50:50,
65:35, 75:25 and 85:15. PLGA can be dissolved in a wide range of
solvents - higher lactide polymers can be dissolved using chlorinated
solvents whereas higher glycolide polymers will require the use of
fluorinated solvents such as HFIP.